Direct electrochemical regeneration of monooxygenase subunits for biocatalytic asymmetric epoxidation.
نویسندگان
چکیده
We report the first example of direct electrochemical regeneration of a flavin-dependent monooxygenase for asymmetric epoxidation catalysis. It is shown that electrochemical regeneration of the oxygenase subunit of the multicomponent styrene monooxygenase is sufficient to perform enantiospecific S-epoxidation of various styrene derivatives. Kinetic bottlenecks of the novel electroenzymatic reaction are identified. This work opens up new alternatives for asymmetric oxyfunctionalization catalysis.
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ورودعنوان ژورنال:
- Journal of the American Chemical Society
دوره 127 18 شماره
صفحات -
تاریخ انتشار 2005